Reply to Walker and Stickgold: Proposed boundary conditions on memory reconsolidation will require empirical verification

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Reply to Walker and Stickgold: Proposed boundary conditions on memory reconsolidation will require empirical verification.

Broadly speaking, nonreplications of the kind we reported (1) can occur for three reasons: (i) the original finding was a false-positive, (ii) the replication was a false-negative, or (iii) some unanticipated variablemoderated the effect. The authors of the original study, Walker and Stickgold (2), now propose several potential moderators (3). We welcome such discussion; however, we should note...

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Understanding the boundary conditions of memory reconsolidation.

Hardwicke et al.’s article (1) challenges the concept that reactivating human memories, by way of retrieval, returns them to a labile form requiring reconsolidation. Several lessons emerge from their study. Although the authors replicate the majority of our original observations (2) (learning, offline consolidation), they observed no evidence for memory lability following retrieval. Three metho...

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Reply to Walker et al.

TO THE EDITOR—We thank Walker et al for their interest in our work [1]. Our study found no evidence of difference in clinical severity of Clostridium difficile infection (CDI) between patients infected with ribotype 027/078 strains compared with others, when adjusted for other co-variates [2]. Adjustment for factors on the hypothesized causal pathway between exposure (ribotype) and outcome (sev...

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In Search for Boundary Conditions of Reconsolidation: A Failure of Fear Memory Interference

The presentation of a fear memory cue can result in mere memory retrieval, destabilization of the reactivated memory trace, or the formation of an extinction memory. The interaction between the degree of novelty during reactivation and previous learning conditions is thought to determine the outcome of a reactivation session. This study aimed to evaluate whether contextual novelty can prevent c...

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Reply to Will and Hegselmann

1. Most importantly, they call attention to the need for replication of computational models. 2. They point out the importance of publishing source code and/or making the code publicly available. 3. They highlight the need for papers to have as much detail as possible about model assumptions, within the constraints of length (which has the additional benefit of keeping models simple enough to b...

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ژورنال

عنوان ژورنال: Proceedings of the National Academy of Sciences

سال: 2016

ISSN: 0027-8424,1091-6490

DOI: 10.1073/pnas.1608235113